منابع مشابه
Screening and Characterization of Microorganisms capable of producing antineoplastic drug, L-asparaginase
Original Article L-asparaginase Screening Characterization Bacillus spp ITBHU02
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Deregulation of c-Myc plays a central role in the tumorigenesis of many human cancers. Yet, the development of drugs regulating c-Myc activity has been challenging. To facilitate the identification of c-Myc inhibitors, we developed a molecular imaging sensor-based high-throughput screening (HTS) system. This system uses a cell-based assay to detect c-Myc activation in a HTS format, which is est...
متن کاملAntineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective
Antineoplastic drugs can be associated with several side effects, including cardiovascular toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX. Chemoterapeutic agents can alter redox homeostasis by increasing the production of reactive oxygen species (ROS) and reactive nitrogen species RNS. Cellular sources of ROS/RNS are cardiomyocytes, endothelial cells, stromal and...
متن کاملReevaluation of a screening program for antineoplastic agents.
A total of 389 compounds and 40 antibiotics were active in the sequential screening program for antineoplastic agents at Lederle Laboratories during the past 8 years . Many of these compounds were folic acid , alkylating agents , or nicotinamide antagonists (thiad.tazoles) . The distribution of anti neoplastic activity against the 3-tumor screen (Sarcoma 180 , 6C3HED ym, and 72j mammary adenoca...
متن کاملPoint-of-Care for Therapeutic Drug Monitoring of Antineoplastic Drugs
Copyright: © 2016 Polo F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In the clinical practice, therapeutic drug monitoring (TDM) concerns the analytical determination of pharmaceutical drug concent...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1992
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/84.16.1288